Glycogen storage: Anderson’s (IV) vs. Cori’s (III) enzyme defect
ABCD:
Anderson’s=Branching enzyme.
Cori’s=Debranching enzyme.
Otherwise, can’t really distinguish clinically.
 
Glycogen storage: names of types I through VI
“Viagra Pills Cause AMajor Hardon”:

• Von Gierke’s
• Pompe’s
• Cori’s
• Anderson’s
• McArdle’s
• Her’s

 Type 1 glycogen storage disease
Type 1 = one (Von), ie Von Giereke’s disease

Glycolysis steps
“Goodness Gracious, Father Franklin Did Go By Picking Pumpkins (to) Prepare Pies”:

• Glucose
• Glucose-6-P
• Fructose-6-P
• Fructose-1,6-diP
• Dihydroxyacetone-P
• Glyceraldehyde-P
• 1,3-Biphosphoglycerate
• 3-Phosphoglycerate
• 2-Phosphoglycerate (to)
• Phosphoenolpyruvate [PEP]
• Pyruvate

‘Did’, ‘By’ and ‘Pies’ tell you the first part of those three: di-, bi-, and py-.
‘PrEPare’ tells location of PEP in the process.
Phosphorylation cascade: action during low glucose
“In the Phasted State, Phosphorylate”:
The phosphorylation cascade becomes active when blood glucose is low.
Citric acid cycle compounds
“Oh Citric Acid Is Of (course) A SiLly STupid Funny Molecule”:

• Oxaloacetate
• Citrate
• Aconitate
• Isocitrate
• Oxalosuccinate
• Alpha-ketoglutarate
• SLucciny-CoA
• STuccinae
• Fumarate
• Malate

SilLy and sTupid used to differentiate succinyL and succinaTe

Citric acid cycle compounds
“Can I Keep Selling Sex For Money, Officer?”:

• Citrate
• Isocitrate
• alpha Ketogluterate
• Succinyl CoA
• Succinate
• Fumerate
• Malate
• Oxaloacetate

Citric acid cycle compounds
“Oh! Can I Keep Some Succinate For Myself?”:

• Oxaloacetate
• Citrate
• Isocitrate
• Ketoglutarate
• Succinyl coA
• Succinate
• Fumarate
• Malate

Citric acid cycle compounds
“Our City Is Kept Safe And Sound From Malice”:

• Oxaloacetate
• Citrate
• Isocitrate
• alpha-Ketoglutarate
• Succinyl-CoA
• Succinate
• Fumarate
• Malate

Citric acid cycle compounds
“Can I Ask Sharon Stone For My Orgasm?”:

• Citrate
• Isocitrate
• Alpha-Ketoglutarate
• Succinyl CoA
• Succinate
• Fumerate
• Maleate
• Oxaloacetate

Dicarboxylic acids (alpha, omega) C2 through C10: common names
“Oh My, Such Good Apple Pie, Sweet As Sugar!”:

• Oxalic
• Malonic
• Succinic
• Glutaric
• Adipic
• Pimelic
• Suberic
• Azelaic
• Sebacic

Galactosaemia: enzyme deficiency
GALIPUT:
Galactose 1 Phosphate Uridyl Transferase.
There is an assay called the Galiput test for this.
Hyperglycemia: 3 classic signs and symptoms
DKA

• Dehydrated
• Ketoacidosis
• Acetone breath

Collagen concisely covered
COLLAGEN:

• C-terminal propeptide (procollagen)/ Covalent Cross links/ C vitamin/ Connective tissue/ Cartilage/ Chondroblasts/ Copper Cofactor (Covalent Cross linking)
• Outside the cell is where collagen normally functions/ Osteoblasts/ Osteogenesis imperfecta
• Lysyl hydroxylase/ Lysyl oxidase (oxidatively deaminates lysyl and hydroxylysyl residues to form collagen cross links, last biosynthesis step)
• Long triple helical fibers/ Ligaments
• Alpha chains/ Attached by H bonds form triple helix/ Ascorbate for hydroxylation of lysyl and prolyl residues of pro-Alpha chains (postranslational modification)
• Gly in every third position/ Glycosylation of hydroxyl group of hydroxylysine with Glucose and Galactose; GOlgi allows procollagen to GO outside of cell
• Extracellular matrix/ Eye (cornea, sclera)/ Ehlers-Danlos Syndrome
• N-terminal propeptide (procollagen)/ Nonhelical terminal extensions

Note: Procollagen LEAVEs the cell to be cLEAVEd by procollagen peptidases
G6PD: oxidant drugs inducing hemolytic anemia
AAA:

• Antibiotic (eg: sufamethoxazole)
• Antimalarial (eg: primaquine)
• Antipyretics (eg: acetanilid, but not aspirin or acetaminophen)

Carbon monoxide: electron transport chain target
“CO blocks CO”:
Carbon monoxide (CO) blocks Cytochrome Oxidase (CO) 
Electron transport chain: Rotenone’s site of action
Rotenone is a site specific inhibitor of complex one.
Malate-aspartate shuttle
“MAD commute”:
Malate in.
Alpha-ketoglutarate and D (Aspartate) out.

Glycolysis Goodness (Glucose) Gracious, (Glucose-6-P) Father (Fructose-6-P) Franklin (Fructose-1,6-diP) Did (Dihydroxyacetone-P) Go (Glyceraldehyde-P) By (1,3-Biphosphoglycerate) Picking (3-phosphoglycerate) Pumpkins (2-phosphoglycerate) (to) PrEPare (Phosphoenolpyruvate [PEP]) Pies (Pyruvate)

Citric Acid Cycle Oh (Oxaloacetate) Citric (Citrate) Acid (Aconitate) Is (Isocitrate) Of course (Oxalosuccinate) A (Alpha-ketoglutarate) SiLly (Succinyl-CoA) STupid (Succinate) Funny (Fumarate) Molecule (Malate)