Miscellaneous
Miscellaneous
G protein type for respective receptors
“KISS and KICK till you’re SICK of SEX” (QISS and QIQ till you’re SIQ of SQS):
This gives the G-protein type (Gq,Gi , or Gs) for all the receptors. Receptors are in alphabetical order:
Golgi complex: functions
“Golgi Distributes A SPAM“:
Metabolic acidosis (normal anion-gap): causes
With hyperkalemia: RAISE K+:
With hypokalemia: ReDUCE K+:
Metabolism sites
“Use both arms to HUG“:
Na/K pump action
(Sing loudlyto the chorus of “Kiss Him Goodbye”): “Na, Na, Na — out! Na, Na, Na — out! K, Kgoes … inside!”
Action ofpump is 3 Na out and 2 K in
Na/K pump: concentrations of Na vs. K on inside/outside ofcell , pump action, number of molecules moved
HIKIN‘:
There is a HIgh K concentration INside the cell.
From this can deduce that the Na/K pump pumps K intocell and Na out of cell .
Alternatively: When I was learning this pump (circa 1992), a band that was “in” was Kris Kross, and a band that was “out” was “Sha Na Na Na“:
So pump moves K K (2 K) in and Na Na Na (3 Na) out.
Sadly, as infectious as their debut album was, Kris Kross can really no longer be classed as “in”.
Na+/K+ pump: movement of ions and quantity
K+ and in each consist of 2 characters, so so 2 K+ are pumped in.
Na+ and out each consist of 3 characters, so 3 Na+ are pumped out.
Tangier’s disease: hallmark
“Tangierene tonsils”:
Hallmark is large orange tonsils.
Important clinical note: there is no increased risk of atherosclerosis, just like eatingtangerenes .
Cell division
“People Meet And Talk.”
“KISS and KICK till you’re SICK of SEX” (QISS and QIQ till you’re SIQ of SQS):
This gives the G-protein type (Gq,
- alpha1=Q
- alpha2=I
- beta1=S
- beta3=S
- M1=Q
- M2=I
- M3=Q
- D1=S
- D2=I
- H1=Q
- H2=S
- V1=Q
- V2=S
Golgi complex: functions
“Golgi Distributes A SPAM“:
- Distributes proteins and lipids from ER
- Add
mannose onto specificlysosome proteins - S
ulfation of sugars andslected tyrosine - P
roteoglycan assembly - Add O-
oligosugars to serine andthrenonine - Modify
N -ologosugars onasparagine
Metabolic acidosis (normal anion-gap): causes
With hyperkalemia: RAISE K+:
- RTA type 4
- A
ldosterone ormineralocorticord deficiency - I
atrogenic : NH4Cl, HCl - “S
tenosis ”: obstructive uropathy - Early uremia
With hypokalemia: ReDUCE K+:
- Renal TA type 1 and 2
- D
iarrhoea - Urine diversion into gut
- Carbonate anhydrase inhibitor
- Ex-hyperventilation
Metabolism sites
“Use both arms to HUG“:
- Heme synthesis
- Urea cycle
- G
luconeogenesis
Na/K pump action
(Sing loudly
Action of
Na/K pump: concentrations of Na vs. K on inside/outside of
HIKIN‘:
There is a HIgh K concentration INside the cell.
From this can deduce that the Na/K pump pumps K into
Alternatively: When I was learning this pump (circa 1992), a band that was “in” was Kris Kross, and a band that was “out” was “Sha Na Na Na“:
So pump moves K K (2 K) in and Na Na Na (3 Na) out.
Sadly, as infectious as their debut album was, Kris Kross can really no longer be classed as “in”.
Na+/K+ pump: movement of ions and quantity
K+ and in each consist of 2 characters, so so 2 K+ are pumped in.
Na+ and out each consist of 3 characters, so 3 Na+ are pumped out.
Tangier’s disease: hallmark
“Tangier
Hallmark is large orange tonsils.
Important clinical note: there is no increased risk of atherosclerosis, just like eating
Cell division
“People Meet And Talk.”
- P
rophase - M
etaphase - A
naphase - T
elophase
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