Miscellaneous

7:07 AM Vamsi Krishna 0 Comments

Miscellaneous

G protein type for respective receptors
KISS and KICK till you’re SICK of SEX” (QISS and QIQ till you’re SIQ of SQS):
This gives the G-protein type (Gq, Gi, or Gs) for all the receptors. Receptors are in alphabetical order:
  • alpha1=Q
  • alpha2=I
  • beta1=S
  • beta3=S
  • M1=Q
  • M2=I
  • M3=Q
  • D1=S
  • D2=I
  • H1=Q
  • H2=S
  • V1=Q
  • V2=S

Golgi complex: functions
“Golgi Distributes A SPAM“:
  • Distributes proteins and lipids from ER
  • Add mannose onto specific lysosome proteins
  • Sulfation of sugars and slected tyrosine
  • Proteoglycan assembly
  • Add O-oligosugars to serine and threnonine
  • Modify N-ologosugars on asparagine

Metabolic acidosis (normal anion-gap): causes
With hyperkalemia: RAISE K+:
  • RTA type 4
  • Aldosterone or mineralocorticord deficiency
  • Iatrogenic: NH4Cl, HCl
  • Stenosis”: obstructive uropathy
  • Early uremia

With hypokalemia: ReDUCE K+:
  • Renal TA type 1 and 2
  • Diarrhoea
  • Urine diversion into gut
  • Carbonate anhydrase inhibitor
  • Ex-hyperventilation

Metabolism sites
“Use both arms to HUG“:
  • Heme synthesis
  • Urea cycle
  • Gluconeogenesis
These reactions occur in both cytoplasm and mitochondria.

Na/K pump action
(Sing loudly to the chorus of “Kiss Him Goodbye”): “NaNaNa — outNaNaNa — outKKgoesinside!”
Action of pump is 3 Na out and 2 K in

Na/K pump: concentrations of Na vs. K on inside/outside of cell, pump action, number of molecules moved
HIKIN‘:
There is a HIgh K concentration INside the cell.
From this can deduce that the Na/K pump pumps K into cell and Na out of cell.
Alternatively: When I was learning this pump (circa 1992), a band that was “in” was Kris Kross, and a band that was “out” was “Sha Na Na Na“:
So pump moves K K (2 K) in and Na Na Na (3 Na) out.
Sadly, as infectious as their debut album was, Kris Kross can really no longer be classed as “in”.

Na+/K+ pump: movement of ions and quantity
K+ and in each consist of characters, so so 2 K+ are pumped in.
Na+ and out each consist of characters, so 3 Na+ are pumped out.

 Tangier’s disease: hallmark
Tangierene tonsils”:
Hallmark is large orange tonsils.
Important clinical note: there is no increased risk of atherosclerosis, just like eating tangerenes.

Cell division
People Meet And Talk.”
  • Prophase
  • Metaphase
  • Anaphase
  • Telophase

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