Protein

7:02 AM Vamsi Krishna 0 Comments

Protein

Catabolism steps of branched chain amino acids
Truck hit the Ox to Death”:
  • Transamination
  • Oxidative decarboxylation
  • Dehydrogenation

Essential amino acids
PVT. TIM HALL:
  • Phe
  • Val
  • Thr
  • Trp
  • Ile
  • Met
  • His
  • Arg
  • Leu
  • Lys
Pvt. is short for Private in the military.
Arg and His are considered semiessential.
Alternatively: “MATT VIL PHLy”.

Essential amino acids
PVT. TIM HALL always argues, never tires”:
  • Phe
  • Val
  • Thr
  • Trp
  • Ile
  • Met
  • His
  • Arg
  • Lue
  • Lys
Always argues: the A is for Arg, not Asp.
‘Never tires': T is not Tyr, but is both Thr and Trp.

Fasting state: branched-chain amino acids used by skeletal muscles
“Muscles LIVe fast”:
  • Leucine
  • Isoleucine
  • Valine
 AcetylCoA and acetacetylCoA: amino acids forming them
A Lighter Lease” (A LyTr LeIs):
  • A=AcetylCoA or Acetoacetyl CoA
  • Ly=Lysine
  • Tr=Tryptophan
  • Le=Leucine
  • Is=Isoleucine
BUN:creatinine elevation: causes
ABCD:
  • Azotremia (pre-renal)
  • Bleeding (GI)
  • Catabolic status
  • Diet (high protein parenteral nutrition)
Creatine phosphate: amino acid precursors
“Nice GAMs!”:
  • Glycine
  • Arginine
  • Methionine
Gam is slang for a person’s leg, especiallay an attractive female’s leg: “Nice gams = nice legs!”
Creatine phosphate is a muscle energy store, and spontaneously converts to creatinine which is excreted in the urine in direct proportion to muscle mass: clinically useful, such as in MS Dx.

Nitric oxide: amino acid precursor
When the dentist works on your teeth, you say, “AAArg! (Arginine)” before he administersNitric Oxide (NO) to take the pain away.
Other players necessary for NO synthesis: NO synthase, Ca++, NADPH.

Urea Cycle
Ordinarily, Careless Crappers, Are Also Frivolous About Urination.
  • Ornithine
  • Carbamoyl
  • Citrulline
  • Arginosuccinate
  • Aspartate
  • Fumarate
  • Arginine
  • Urea

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